Publications
Publications are a key productivity measure and give a sense of the capabilites of the Facilty. This page is intended to document the depth and breadth of the work that has been done at the Facility.
Breakdown by:
A complete list of papers describing work that made use of the Facility appears below.
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Allen SJ, Zabel BA, Kirkpatrick J, Butcher EC, Nietlispach D, Handel TM
NMR assignment of human chemerin, a novel chemoattractant.
Biomol NMR Assign. 2007 Dec;1(2):171-3 -
Hughes CC, MacMillan JB, Gaudêncio SP, Jensen PR, Fenical W
The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species.
Angew Chem Int Ed Engl. 2009;48(4):725-7 -
Winter JM, Jansma AL, Handel TM, Moore BS
Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone.
Angew Chem Int Ed Engl. 2009 Jan 12;48(4):767-70 -
Morinaka BI, Pawlik JR, Molinski TF
Amaroxocanes A and B: sulfated dimeric sterols defend the Caribbean coral reef sponge Phorbas amaranthus from fish predators.
J Nat Prod. 2009 Feb 27;72(2):259-64 -
Dalisay DS, Rogers EW, Edison AS, Molinski TF.
Structure elucidation at the nanomole scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus.
J Nat Prod. 2009 Apr;72(4):732-8 -
Dalisay DS, Molinski TF
NMR quantitation of natural products at the nanomole scale.
J Nat Prod. 2009 Apr;72(4):739-44. -
Dalisay DS, Molinski TF
Structure elucidation at the nanomole scale. 2. Hemi-phorboxazole A from Phorbas sp.
Org Lett. 2009 May 7;11(9):1967-70 -
Dalisay DS, Morinaka BI, Skepper CK, Molinski TF.
A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale.
J Am Chem Soc. 2009 Jun 10;131(22):7552-3 -
Pereira A, Cao Z, Murray TF, Gerwick WH
Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria.
Chem Biol. 2009 Aug 28;16(8):893-906 -
Soria-Mercado IE, Pereira A, Cao Z, Murray TF, Gerwick WH
Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.
Org Lett. 2009 Oct 15;11(20):4704-7 -
Pereira AR, McCue CF, Gerwick WH
Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii.
J Nat Prod. 2010 Feb 26;73(2):217-20 -
Pereira AR, Byrum T, Shibuya GM, Vanderwal CD, Gerwick WH
Structure revision and absolute configuration of malhamensilipin A from the freshwater chrysophyte Poterioochromonas malhamensis.
J Nat Prod. 2010 Feb 26;73(2):279-83 -
Schultz AW, Lewis CA, Luzung MR, Baran PS, Moore BS
Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides.
J Nat Prod. 2010 Mar 26;73(3):373-7 -
Wang YG, Morinaka BI, Reyes JC, Wolff JJ, Romo D, Molinski TF
Synthesis of 7-(15)N-Oroidin and evaluation of utility for biosynthetic studies of pyrrole-imidazole alkaloids by microscale (1)H-(15)N HSQC and FTMS.
J Nat Prod. 2010 Mar 26;73(3):428-34 -
Choi H, Engene N, Smith JE, Preskitt LB, Gerwick WH
Crossbyanols A-D, toxic brominated polyphenyl ethers from the Hawai'ian bloom-forming Cyanobacterium Leptolyngbya crossbyana.
J Nat Prod. 2010 Apr 23;73(4):517-22 -
Dalisay DS, Molinski TF
Structure elucidation at the nanomole scale. 3. Phorbasides G-I from Phorbas sp.
J Nat Prod. 2010 Apr 23;73(4):679-82 -
Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA
Structure of the minimal interface between ApoE and LRP.
J Mol Biol. 2010 Apr 30;398(2):306-19 -
Jansma AL, Kirkpatrick JP, Hsu AR, Handel TM, Nietlispach D
NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27.
J Biol Chem. 2010 May 7;285(19):14424-37. doi: 10.1074/jbc.M109.091108. Epub 2010 Mar 3. PMID: 20200157 -
Severin IC, Gaudry JP, Johnson Z, Kungl A, Jansma A, Gesslbauer B, Mulloy B, Power C, Proudfoot AE, Handel T
Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.
J Biol Chem. 2010 Jun 4;285(23):17713-24 -
Choi H, Pereira AR, Cao Z, Shuman CF, Engene N, Byrum T, Matainaho T, Murray TF, Mangoni A, Gerwick WH
The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria.
J Nat Prod. 2010 Aug 27;73(8):1411-21 -
Pereira AR, Cao Z, Engene N, Soria-Mercado IE, Murray TF, Gerwick WH
Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.
Org Lett. 2010 Oct 15;12(20):4490-3 -
Molinski TF, Ko J, Reynolds KA, Lievens SC, Skarda KR
N,N'-methyleno-didemnin A from the ascidian Trididemnum solidum. Complete NMR assignments and confirmation of the imidazolidinone ring by strategic analysis of 1J(CH).
J Nat Prod. 2011 Apr 25;74(4):882-7 -
Mevers E, Liu WT, Engene N, Mohimani H, Byrum T, Pevzner PA, Dorrestein PC, Spadafora C, Gerwick WH
Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera.
J Nat Prod. 2011 May 27;74(5):928-36 -
Pereira AR, Etzbach L, Engene N, Müller R, Gerwick WH
Molluscicidal metabolites from an assemblage of Palmyra Atoll cyanobacteria.
J Nat Prod. 2011 May 27;74(5):1175-81 -
Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH
Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera.
J Nat Prod. 2011 Aug 26;74(8):1737-43 -
Miyanaga A, Janso JE, McDonald L, He M, Liu H, Barbieri L, Eustáquio AS, Fielding EN, Carter GT, Jensen PR, Feng X, Leighton M, Koehn FE, Moore BS
Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria.
J Am Chem Soc. 2011 Aug 31;133(34):13311-3 -
Gutiérrez M, Pereira AR, Debonsi HM, Ligresti A, Di Marzo V, Gerwick WH
Cannabinomimetic lipid from a marine cyanobacterium.
J Nat Prod. 2011 Oct 28;74(10):2313-7 -
Morinaka BI, Molinski TF
Mollenyne A, a long-chain chlorodibromohydrin amide from the sponge Spirastrella mollis.
Org Lett. 2011 Dec 16;13(24):6338-41 -
Choi H, Proteau PJ, Byrum T, Pereira AR, Gerwick WH
Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicata.
Phytochemistry. 2012 Jan;73(1):134-41 -
Pereira AR, Kale AJ, Fenley AT, Byrum T, Debonsi HM, Gilson MK, Valeriote FA, Moore BS, Gerwick WH
The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium.
Chembiochem. 2012 Apr 16;13(6):810-7 -
Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH
Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
J Org Chem. 2012 May 4;77(9):4198-208 -
Stout EP, Wang YG, Romo D, Molinski TF.
Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.
Angew Chem Int Ed Engl. 2012 May 14;51(20):4877-81 -
Fuglestad B, Gasper PM, Tonelli M, McCammon JA, Markwick PR, Komives EA.
The dynamic structure of thrombin in solution.
Biophys J. 2012 Jul 3;103(1):79-88 -
Moree WJ, Phelan VV, Wu CH, Bandeira N, Cornett DS, Duggan BM, Dorrestein PC.
Interkingdom metabolic transformations captured by microbial imaging mass spectrometry.
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13811-6 -
Choi H, Mevers E, Byrum T, Valeriote FA, Gerwick WH.
Lyngbyabellins K-N from Two Palmyra Atoll Collections of the Marine Cyanobacterium Moorea bouillonii.
European J Org Chem. 2012 Sep 1;2012(27):5141-5150 -
Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.
Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.
Biochem J. 2013 Feb 15;450(1):231-42 -
Molinski TF, Biegelmeyer R, Stout EP, Wang X, Frota ML Jr, Henriques AT
Halisphingosines A and B, modified sphingoid bases from Haliclona tubifera. Assignment of configuration by circular dichroism and van't Hoff's principle of optical superposition.
J Nat Prod. 2013 Mar 22;76(3):374-81 -
Watrous JD, Phelan VV, Hsu CC, Moree WJ, Duggan BM, Alexandrov T, Dorrestein PC
Microbial metabolic exchange in 3D.
ISME J. 2013 Apr;7(4):770-80 -
Januar LA, Molinski TF
Acremolin from Acremonium strictum is N(2),3-etheno-2'-isopropyl-1-methylguanine, not a 1H-azirine. Synthesis and structural revision.
Org Lett. 2013 May 17;15(10):2370-3 -
de Gracia Lux C, Almutairi A
Intramolecular Cyclization for Stimuli-Controlled Depolymerization of Polycaprolactone Particles Leading to Disassembly and Payload Release.
ACS Macro Lett. 2013 May 21;2(5):432-435. -
Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore BS
Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica.
Chembiochem. 2013 May 27;14(8):955-62 -
Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore BS, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC
MS/MS networking guided analysis of molecule and gene cluster families.
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2611-20 -
Jang KH, Nam SJ, Locke JB, Kauffman CA, Beatty DS, Paul LA, Fenical W.
Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete.
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7822-4 -
Olejniczak J, Sankaranarayanan J, Viger ML, Almutairi A
Highest Efficiency Two-Photon Degradable Copolymer for Remote Controlled Release.
ACS Macro Lett. 2013 Aug 20;2(8):683-687. -
Suarez S, Grover GN, Braden RL, Christman KL, Almutairi A
Tunable protein release from acetalated dextran microparticles: a platform for delivery of protein therapeutics to the heart post-MI.
Biomacromolecules. 2013 Nov 11;14(11):3927-35. -
Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore BS
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules.
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4407-16 -
Mantovani SM, Moore BS
Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A.
J Am Chem Soc. 2013 Dec 4;135(48):18032-5. -
Lux J, Chan M, Elst LV, Schopf E, Mahmoud E, Laurent S, Almutairi A
Metal Chelating Crosslinkers Form Nanogels with High Chelation Stability.
J Mater Chem B Mater Biol Med. 2013 Dec 14;1(46):6359-6364. -
Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore BS, Gerwick WH, Linington RG, Pogliano K, Dorrestein PC
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus.
J Antibiot (Tokyo). 2014 Jan;67(1):99-104 -
Farnaes L, Coufal NG, Kauffman CA, Rheingold AL, DiPasquale AG, Jensen PR, Fenical W
Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.
J Nat Prod. 2014 Jan 24;77(1):15-21 -
Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
Proc Natl Acad Sci U S A. 2014 Feb 4; 111(5), pp 1957-62 -
Wang X, Morinaka BI, Molinski TF
Structures and Solution Conformational Dynamics of Stylissamides G and H from the Bahamian Sponge Stylissa caribica.
J Nat Prod. 2014 Mar 28;77(3):625-30 -
Mevers E, Haeckl FP, Boudreau PD, Byrum T, Dorrestein PC, Valeriote FA, Gerwick WH
Lipopeptides from the Tropical Marine Cyanobacterium Symploca sp.
J Nat Prod. 2014 Apr 25;77(4):969-75 -
Trivella DB, Pereira AR, Stein ML, Kasai Y, Byrum T, Valeriote FA, Tantillo DJ, Groll M, Gerwick WH, Moore BS.
Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.
Chem Biol. 2014 Jun 19;21(6):782-91 -
Stout EP, Choi MY, Castro JE, Molinski TF
Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies.
J Med Chem. 2014 Jun 26;57(12):5085–5093 -
Kaczanowska K, Harel M, Radić Z, Changeux JP, Finn MG, Taylor P
Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
Proc Natl Acad Sci USA. 2014 Jul 22;111(29):10749-54 -
Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore BS
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria.
Nat Chem Biol. 2014 Aug;10(8):640-7 -
Agarwal V, Moore BS
Enzymatic Synthesis of Polybrominated Dioxins from the Marine Environment.
ACS Chem Biol. 2014 Sep 19;9(9):1980-4 -
Teufel R, Kaysser L, Villaume MT, Diethelm S, Carbullido MK, Baran PS, Moore BS
One-Pot Enzymatic Synthesis of Merochlorin A and B.
Angew Chem Int Ed Engl. 2014 Oct 6;53(41):11019-22 -
Diethelm S, Teufel R, Kaysser L, Moore BS
A Multitasking Vanadium-Dependent Chloroperoxidase as an Inspiration for the Chemical Synthesis of the Merochlorins.
Angew Chem Int Ed Engl. 2014 Oct 6;53(41):11023-6 -
Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick WH, Gutiérrez M, Dorrestein PC
Microbiota of healthy corals are active against fungi in a light-dependent manner.
ACS Chem Biol. 2014 Oct 17;9(10):2300-8 -
Mevers E, Matainaho T, Allara' M, Di Marzo V, Gerwick WH
Mooreamide A: A Cannabinomimetic Lipid from the Marine Cyanobacterium Moorea bouillonii.
Lipids. 2014 Nov;49(11):1127-32 -
Jamison MT, Boddy CN, Molinski TF
Salvadenosine, a 5'-Deoxy-5'-(methylthio) Nucleoside from the Bahamian Tunicate Didemnum sp.
J Org Chem. 2014 Nov 7;79(21):9992-9997 -
Mehrotra S, Duggan BM, Tello-Aburto R, Newar TD, Gerwick WH, Murray TF, Maio WA
Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists.
J Nat Prod. 2014 Nov 26;77(11):2553-60 -
Lux J, White AG, Chan M, Anderson CJ, Almutairi A
Nanogels from Metal-Chelating Crosslinkers as Versatile Platforms Applied to Copper-64 PET Imaging of Tumors and Metastases.
Theranostics. 2015 Jan 1;5(3):277-88 -
Carling CJ, Viger ML, Huu VA, Garcia AV, Almutairi A
In vivo vivsible light-triggered drug release from an implanted depot
Chem. Sci. 2015 Jan 1;6(1):335-341 -
Agarwal V, Li J, Rahman I, Borgen M, Aluwihare LI, Biggs JS, Paul VJ, Moore BS
Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry.
Environ Sci Technol. 2015 Feb 3;49(3):1339-46 -
Huu VA, Luo J, Zhu J, Zhu J, Patel S, Boone A, Mahmoud E, McFearin C, Olejniczak J, de Gracia Lux C, Lux J, Fomina N, Huynh M, Zhang K, Almutairi A.
Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye.
J Control Release. 2015 Feb 28;200:71-7 -
Bonet B, Teufel R, Crüsemann M, Ziemert N, Moore BS
Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin.
J Nat Prod. 2015 Mar 27;78(3):539-42 -
Jamison MT, Molinski TF
Antipodal Crambescin A2 Homologues from the Marine Sponge Pseudaxinella reticulata. Antifungal Structure-Activity Relationships.
J Nat Prod. 2015 Mar 27;78(3):557-61 -
Duncan KR, Crüsemann M, Lechner A, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, Moore BS, Dorrestein PC, Jensen PR
Molecular Networking and Pattern-Based Genome Mining Improves Discovery of Biosynthetic Gene Clusters and their Products from Salinispora Species.
Chem Biol. 2015 Apr 23;22(4):460-71 -
Grover GN, Garcia J, Nguyen MM, Zanotelli M, Madani MM, Christman KL
Binding of Anticell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues.
Adv Healthc Mater. 2015 Jun 24;4(9):1327-31 -
Richter TK, Hughes CC, Moore BS
Sioxanthin, a novel glycosylated carotenoid reveals an unusual subclustered biosynthetic pathway.
Environ Microbiol. 2015 Jun;17(6):2158-71 -
Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS
Salinipyrone and pacificanone are biosynthetic byproducts of the rosamicin polyketide synthase.
Chembiochem. 2015 Jul 6;16(10):1443-7 -
Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH
Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria.
J Nat Prod. 2015 Jul 24;78(7):1671-82 -
Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH
Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.
PLOS One. 2015 Jul 29;10(7):e0133297 -
Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP
Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria.
Angew Chem Int Ed Engl. 2015 Jul 31;54(38):11063-7 -
Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W
The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.
Chembiochem. 2015 Aug 12;16(14):2002-6 -
Wang X, Duggan BM, Molinski TF
Mollenynes B-E from the Marine Sponge Spirastrella mollis. Band-Selective HSQC for Discrimination of Bromo-chloro Regioisomerism in Natural Products.
J Am Chem Soc. 2015 Sep 3;137(38):12343-51 -
Olejniczak J, Nguyen Huu VA, Lux J, Grossman M, He S, Almutairi A
Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.
Chem Commun. 2015 Nov 17;51(95):16980-3 -
Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining.
ACS Chem Biol. 2015 Dec 18;10(12):2841-9 -
Ray L, Yamanaka K, Moore BS
A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis.
Angew Chem Int Ed Engl. 2016 Jan 4;55(1):364-7 -
Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH
The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide.
Chembiochem. 2016 Jan;17(2):164-73 -
Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick WH
Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities.
Phytochemistry. 2016 Feb;122:113-8 -
White AR, Duggan BM, Tsai SC, Vanderwal CD
The Alga Ochromonas danica Produces Bromosulfolipids.
Org Lett. 2016 Feb 18;18(5):1124-7 -
Carling CJ, Olejniczak J, Foucault-Collet A, Collet G, Viger ML, Huu VA, Duggan BM, Almutairi A
Efficient Red Light Photo-Uncaging of Active Molecules in Water Upon Assembly into Nanoparticles.
Chem Sci. 2016 Mar;7(3):2392-2398 -
Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A
Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction.
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3185-90 -
Jamison MT, Dalisay DS, Molinski TF
Peroxide Natural Products from Plakortis zyggompha and the Sponge Association Plakortis halichondrioides-Xestospongia deweerdtae: Antifungal Activity against Cryptococcus gattii.
J Nat Prod. 2016 Mar 25;79(3):555-63 -
El Gamal A, Agarwal V, Diethelm S, Rahman I, Schorn MA, Sneed JM, Louie GV, Whalen KE, Mincer TJ, Noel JP, Paul VJ, Moore BS
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair.
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3797-802 -
Johnson TC, Chin MR, Han T, Shen JP, Rana T, Siegel D
Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion.
J Am Chem Soc. 2016 May 11;138(18):6068-73 -
Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, Boya P CA, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJ, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AM, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BØ, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.
Nat Biotechnol. 2016 Aug 9;34(8):828-837 -
Jamison MT, Molinski TF
Jamaicensamide A, a Peptide Containing β-Amino-α-keto and Thiazole-Homologated η-Amino Acid Residues from the Sponge Plakina jamaicensis.
J Nat Prod. 2016 Sep 23;79(9):2243-9 -
Li ZR, Li J, Gu JP, Lai JY, Duggan BM, Zhang WP, Li ZL, Li YX, Tong RB, Xu Y, Lin DH, Moore BS, Qian PY
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.
Nat Chem Biol. 2016 Oct;12(10):773-5 -
Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL Jr, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, Mot R, Moore BS, Medema MH, Dorrestein PC
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides.
Nat Microbiol. 2016 Oct 31;2:16197 -
Jordan PA, Moore BS
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids.
Cell Chem Biol. 2016 Nov 9. pii: S2451-9456(16)30387-7 -
Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg MH
Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.
Structure. 2016 Dec 6;24(12):2152-2162 -
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Applying a Chemogeographic Strategy for Natural Product Discovery from the Marine Cyanobacterium Moorena bouillonii.
Mar Drugs. 2020 Oct 14;18(10):515 -
Konduri S, Prashanth J, Krishna VS, Sriram D, Behera JN, Siegel D, Rao KP
Design and Synthesis of Purine Connected Piperazine Derivatives as Novel Inhibitors of Mycobacterium tuberculosis.
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Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products.
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Experimental characterization of the association of β-cyclodextrin and eight novel cyclodextrin derivatives with two guest compounds.
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Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.
J Med Chem. 2021 Jan 28;64(2):1073-1102 -
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Discovery and Biosynthesis of Tetrachlorizine Reveals Enzymatic Benzylic Dehydrogenation via an ortho-Quinone Methide.
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Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.
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