Open to all
We provide access to state of the art NMR technology for both UCSD
and external users. Users can collect their own data, facility staff
can do it all for you, or collaborative projects can be developed.
We provide training in instrument operation and can offer advice
for data analysis or project feasibility.
The facility houses two 600 MHz Bruker Avance III spectrometers with
cryogenically cooled probes for enhanced sensitivity. For samples
whose concentration is limited by the amount of material available, or
by solubility, our 1.7 mm microcoil cryoprobe requires just 40 μl of solution.
We accomodate medicinal chemists by allowing walk-up access to
our spectrometers. Standard parameter sets for all common experiments
simplify data acquisition and allow chemists to focus on chemistry.
Natural product studies demand excellent sensitivity
due to the limited availablity of material. Two approaches to increase
sensitivity are combined in our 1.7 mm cryoprobe; cryogenic cooling of
the detection coil and preamplifier, and reduction of sample volume.
Our biomolecular instrument is equipped to handle the demands of modern
methods for studying protein and nucleic acid structure and dynamics.
The quad channel console and the indirect detect cryoprobe enables
acquisition of triple resonance spectra.
Metabolomics demands high throughput and reproducibility to produce
the large datasets necessary to extract correlations. Our BACS-60
sample changer enables automated collection of spectra on up to 60
samples at a time.